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KMID : 0043320110340071201
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Archives of Pharmacal Research
2011 Volume.34 No. 7 p.1201 ~ p.1208
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The antidiabetic effect of ginsenoside Rb2 via activation of AMPK
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Lee Kyoung-Tae
Jung Tae-Woo
Lee Hak-Ju
Kim Seul-Gi
Shin Yu-Su
Whang Wan Kyunn
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Abstract
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Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.
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KEYWORD
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Panax ginseng, Rb2, AMPK, SHP, H4IIE cells
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